Status:
COMPLETED
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
VA Office of Research and Development
Conditions:
Posttraumatic Stress Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The consolidation of learning is enhanced by adrenalin and other stress hormones. This memory enhancing effect is opposed by propranolol. In posttraumatic stress disorder (PTSD), a psychologically tra...
Detailed Description
Background: Animal evidence indicates that some consolidated memories when reactivated (retrieved) need to be reconsolidated. During this process, memories can be enhanced or weakened. In a preliminar...
Eligibility Criteria
Inclusion
- Afghanistan and Iraq War veterans who have been diagnosed as having combat-related PTSD
Exclusion
- PTSD Checklist (PCL) score (administered at the referring site) ≤ 50;
- Current, co-existing PTSD of non-combat origin
- Resting systolic blood pressure \<100 mm Hg
- Medical condition that contraindicates the administration of propranolol
- Previous adverse reaction to, or non-compliance with, a β-adrenergic blocker
- Presence of drugs of abuse
- Pregnancy
- Contraindicating psychiatric condition
- Initiation of, or change in, psychotropic medication within the two months prior to recruitment
- Current use of medication that may involve potentially dangerous interactions with propranolol
- Inability to understand the study's procedures, risks, and side effects, or to otherwise give informed consent for participation
- Does not understand English
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00709735
Start Date
May 1 2007
End Date
August 1 2010
Last Update
April 10 2017
Active Locations (3)
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1
VA Medical Center
Bedford, Massachusetts, United States, 01730
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02108
3
VA Medical Center
Manchester, New Hampshire, United States, 03104