Status:
UNKNOWN
Angiotensin in Septic Kidney Injury Trial
Lead Sponsor:
Austin Health
Collaborating Sponsors:
Northern Health and Social Care Trust
Western Hospital, Australia
Conditions:
Acute Renal Failure
Sepsis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine the effect of a systemic infusion of angiotensin II on haemodynamics and urine output in critically ill patients with severe sepsis/septic shock and acute ren...
Detailed Description
Sepsis is the most common cause of ARF in the ICU. In last 50 years there have been no significant advances in our understanding of the pathogenesis, prevention or treatment of septic ARF, except for ...
Eligibility Criteria
Inclusion
- age ≥ 18 years
- within the first 24 hours of ICU admission
- an expected duration of ICU admission of at least 72 hours
- informed consent by patient or by proxy (i.e. next of kin)
- diagnosis of severe sepsis/septic shock
- diagnosis of kidney dysfunction (minimum RIFLE criteria - 'R'); and
- presence of a central venous catheter.
Exclusion
- inability to provide or obtain consent;
- patient is moribund with expected death within 24 hours;
- known chronic kidney disease (CKD) or end-stage renal disease (ESRD) receiving chronic RRT;
- confirmed or suspected acute glomerulonephritis, acute interstitial nephritis, renal vasculitis or post-renal aetiology for kidney dysfunction;
- patient is already receiving (or is about to start) CRRT for acute renal failure at the time of enrolment;
- known or documented allergy to angiotensin II;
- MAP consistently \> 100 mmHg with no pressor support and no easily treatable cause (eg. pain); and
- enrolling physician's belief that the study drug could not be administered for the expected study duration.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00711789
Start Date
February 1 2010
Last Update
June 23 2011
Active Locations (2)
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1
Northern Hospital
Epping, Victoria, Australia, 3074
2
The Western Hospital
Footscray, Victoria, Australia, 3011