Status:

COMPLETED

Abciximab i.v. Versus i.c. in ST-elevation Myocardial Infarction

Lead Sponsor:

University of Leipzig

Conditions:

ST-elevation Myocardial Infarction

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

The purpose of this study is to examine whether intracoronary abciximab bolus application with subsequent 12 hour intravenous infusion in addition to primary percutaneous coronary intervention is bene...

Detailed Description

In patients with acute ST-elevation myocardial infarction (STEMI) primary percutaneous coronary intervention (PCI) is the preferred reperfusion regimen, if performed by experienced operators in a time...

Eligibility Criteria

Inclusion

  • Clinical symptoms:
  • Angina pectoris \< 12 hours and
  • Persistent angina \> 30 minutes
  • ECG-criteria for ST-elevation myocardial infarction in 12-lead ECG:
  • ST-segment elevation \> 1mm in ≥ 2 extremity leads and/or
  • ST-segment elevation \> 2mm in ≥ 2 adjacent precordial leads
  • Informed consent

Exclusion

  • No informed consent
  • Pregnancy
  • Known allergy to abciximab, ASA or heparin
  • Active peptic ulcus ventriculi or duodeni
  • Active, non-superficial bleeding
  • History of major surgery (including intracranial or intraspinal) \<4 weeks
  • active internal bleeding
  • Cerebrovascular complications \< 2 years
  • Known coagulation defect or thrombocytopenia
  • Arteriovenous malformations or aneurysm
  • Severe liver insufficiency, renal insufficiency requiring dialysis
  • Uncontrolled hypertension, hypertensive retinopathy
  • Vaskulitis
  • Thrombolysis \< 12 h
  • Participation in another trial

Key Trial Info

Start Date :

July 1 2008

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

April 1 2011

Estimated Enrollment :

1912 Patients enrolled

Trial Details

Trial ID

NCT00712101

Start Date

July 1 2008

End Date

April 1 2011

Last Update

April 20 2011

Active Locations (11)

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Page 1 of 3 (11 locations)

1

Zentralklinik Bad Berka

Bad Berka, Germany, 99437

2

Herz- und Gefäß-KLinik Bad Neustadt

Bad Neustadt an der Saale, Germany, 97616

3

Herz und Diabeteszentrum Bad Oeynhausen

Bad Oeynhausen, Germany, 32545

4

Klinikum Links der Weser - Bremen

Bremen, Germany, 28277