Status:
COMPLETED
Neurovascular Coupling in Patients With Early Stage Diabetes Retinopathy
Lead Sponsor:
Gerhard Garhofer
Conditions:
Diabetic Retinopathy
Eligibility:
All Genders
20-50 years
Brief Summary
A variety of studies demonstrate that ocular blood flow is altered in diabetes and retinal perfusion abnormalities have been proposed to contribute to the pathogenesis of diabetic retinopathy. Variou...
Eligibility Criteria
Inclusion
- Men and women aged between 20 and 50 years
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Inclusion criteria of patients are insulin dependent diabetes mellitus (IDDM) with non or mild non-proliferative retinopathy. Patients with no signs of diabetic retinopathy (level 1) or patients with one or more microaneurysms (level 2) will be included. Duration of Diabetes is between 5 and 20 years
- Men and women will be included in equal parts. A pregnancy test will be performed at screening
- Ametropia of less than 3 diopters and anisometropia of less than 1 diopter
Exclusion
- Non insulin dependent diabetes
- Maturity onset diabetes of the young (MODY diabetes)
- Any sign of non diabetes induced vascular pathologies, systemic hypertension (defined as systolic blood pressure \> 150 mm Hg and diastolic blood pressure \> 90 mm Hg.)
- Presence of intraocular pathology other than diabetic retinopathy
- History or family history of epilepsy
- Pregnancy
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00712842
Start Date
January 1 2007
End Date
December 1 2011
Last Update
July 20 2012
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Vienna, Austria, 1090