Status:
COMPLETED
Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Dependence
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
Cocaine dependence is a major public health problem and the development of a treatment for this disorder is a priority. To date, treatment interventions based on positive incentive principles have sho...
Eligibility Criteria
Inclusion
- between 18 and 60 years of age
- meet Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition (DSM-IV) criteria for current cocaine dependence.
- be in acceptable health on the basis of interview, medical history and physical exam.
Exclusion
- current DSM-IV diagnosis of any psychoactive substance dependence other than cocaine, marijuana, or nicotine.
- have a DSM-IV axis I psychiatric disorder or neurological disease or disorder requiring ongoing treatment and/or making study participation unsafe.
- have significant current suicidal or homicidal ideation.
- have medical conditions contraindicating levodopa/carbidopa pharmacotherapy. Conditions include severe pulmonary disease (bronchial asthma, emphysema), cardiovascular disease (severe or history of myocardial infarction with residual arrhythmias), narrow angle glaucoma, melanoma, history of peptic ulcer, renal function impairment.
- taking medications known to have significant drug interactions with levodopa/carbidopa (e.g., monoamine oxidase (MAO) inhibitors, anticonvulsants, haloperidol, phenothiazines, selegiline, anesthetics).
- currently or recently (last 3 months) treated for substance use or another psychiatric condition.
- having conditions of probation or parole requiring reports of drug use to officers of the court.
- impending incarceration.
- pregnant or nursing for female patients.
- inability to read, write, or speak English.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT00713583
Start Date
January 1 2008
End Date
December 1 2011
Last Update
April 23 2018
Active Locations (1)
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1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030