Status:
COMPLETED
Citrulline and Protein Metabolism in the Malnourished Elderly People
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Kyowa Hakko Kogyo (Japan) providing the amino acids
Conditions:
Metabolism
Elderly
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the effects of a supplementation of citrulline for three weeks in elderly malnourished and hospitalised subjects on muscle protein synthesis.
Detailed Description
Malnutrition in the elderly causes an important public health problem because their response to re nutrition is highly decreased. Several experimental studies have shown that an amino acid named citru...
Eligibility Criteria
Inclusion
- elderly hospitalised in geriatric medicine or in following care and rehabilitation, moderately malnourished
- aged more than 70 years
- recent moderate undernutrition (30 g/l \< albuminemia \< 35 g/l and 18 \< BMI \< 22 or a score of the Mini Nutritional Assessment (MNA) \< 17 with albuminemia \> 30 g/l)
- ingesta of at least 20 kcal / kg / d and 0,8 g / kg / d of proteins
Exclusion
- hospitalisation \< 21d
- C reactive protein (CRP) \> 50 mg / l
- end-stage cardiac insufficiency
- severe digestive incapacity
- renal insufficiency (Creatinine Clearance \< 30 ml / mn)
- respiratory failure
- MMS \< 18
- uncontrolled acute or chronic infectious pathology (HIV, tuberculosis)
- corticoids treatment
- evolutionary neoplasia
- palliative phase of severe pathology
- Mental Mini Score status of Folstein (MMS) \< 8
- parenteral nutrition
- active chronic hepatitis or cirrhosis
- participation in another trial
Key Trial Info
Start Date :
December 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT00714675
Start Date
December 1 2009
End Date
January 1 2013
Last Update
December 31 2013
Active Locations (1)
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1
Hôpital Emile Roux
Limeil-Brévannes, France, 94