Status:
COMPLETED
Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS)
Lead Sponsor:
Christine Barr
Collaborating Sponsors:
MDA/ALS Center of Hope
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18-89 years
Brief Summary
Recent evidence implicates abnormalities of autonomic function in ALS including problems with gastrointestinal (GI) motility. GI complaints reported by ALS patients such as constipation, diffuse abdom...
Detailed Description
This study will examine how much time it takes for the food to travel along the intestines from mouth or stomach (if you have a feeding tube) to the end of the large intestine using a special instrume...
Eligibility Criteria
Inclusion
- For the Disease Population:
- Diagnosis of definite or possible ALS by the El Escorial Criteria
- No previously known gastrointestinal problems
- Able to fast and hold medicines (anticholinergics and prokinetics) overnight prior to the measurement of GI motility
- No unstable medical problems and no evidence of dehydration by examination (skin turgor)
- For Healthy Control
- No known gastrointestinal illness
- Able to fast and hold medicines (anticholinergics) overnight prior to the measurement of GI motility
- No unstable medical problems or evidence of dehydration
Exclusion
- Patients or controls who are dehydrated
- Patients or controls who have evidence of previous gastrointestinal disease
- Patients with any unstable medical condition
- Patients unable to give informed consent
- Patients unable to blow into the breath analyzer and have steady breathing for one minute
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2016
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00714805
Start Date
January 1 2007
End Date
November 1 2016
Last Update
January 6 2017
Active Locations (1)
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1
MDA/ALS Center of Hope
Philadelphia, Pennsylvania, United States, 19104