Status:
COMPLETED
Multi-Tracer Pet Quantitation of Insulin Action
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
University of Padova
Conditions:
Diabetes
Eligibility:
All Genders
30-55 years
Brief Summary
We are proposing a clinical investigation of the pathogenesis of insulin resistance (IR) in skeletal muscle and adipose tissue (AT), focusing specifically on the contributions of glucose delivery, tra...
Detailed Description
We propose a clinical investigation of the pathogenesis of insulin resistance (IR) in skeletal muscle and adipose tissue (AT) in obesity and diabetes mellitus, focusing on the separate and interactive...
Eligibility Criteria
Inclusion
- Male and Female Normal Weight - non-diabetic (BMI 19-25) Overweight/Obese - non-diabetic (BMI 27-38) Type 2 DM (BMI 27-38)
- Fasting lab glucose \< 100 mg/dl (non-diabetic groups) HbA1c \< 6.0 (non-diabetic group) HbA1c \< 8.5 (diabetic group)
- Ulnar artery patent bilaterally Negative urine pregnancy test Non-smoker Independent in self blood glucose monitoring (diabetic group)
Exclusion
- BP \> 150 mmHg systolic or \> 95 mmHg diastolic History of any heart disease, including MI, pacemaker History of PVD, (including diminishing pulses) liver disease, kidney disease, pulmonary disease, neuromuscular disease, neurological disease, thyroid disease or any drug or alcohol abuse.
- Current malignancy or history of cancer within the past 5 years Proteinuria 1+ or greater Hematocrit \< 34% sTSH \>8 ALT \> 60; AST \> 60; Alk Phos \> 150 Total cholesterol \> 250 Triglycerides \> 300
- MEDICATIONS:
- Chronic medications that can alter glucose homeostasis: oral glucocorticoids, nicotinic acid (Birth control medications are okay and will not exclude) Thiazolidinediones or insulin, previous difficulty with lidocaine (xylocaine) Gained or lost more than 3 kg during the past 3 months Involved in regular exercise \> 1 day/week Surgical or vascular implants, any metal in body, claustrophic Currently pregnant OR currently lactating
Key Trial Info
Start Date :
July 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00715221
Start Date
July 1 2007
End Date
June 1 2012
Last Update
August 1 2017
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213