Status:
UNKNOWN
High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome
Lead Sponsor:
The University of Western Australia
Conditions:
Metabolic Syndrome X
Eligibility:
All Genders
20-75 years
Brief Summary
The aim of the study is to examine the kinetic, anti-oxidant, anti-inflammatory and cellular cholesterol efflux properties of high-density lipoprotein (HDL) in subjects with the metabolic syndrome (Me...
Detailed Description
Background and Purpose of This Study: The metabolic syndrome (MetS) is characterized by impaired glucose and insulin metabolism (insulin resistance), abnormal body fat distribution called central obe...
Eligibility Criteria
Inclusion
- MetS :the presence of at least three of the following:
- waist circumference \> 102 cm, triglycerides \> 1.7 mmol/L, HDL cholesterol \< 1.05 mmol/L
- blood pressure ≥ 130/ ≥ 85 mmHg
- fasting glucose \> 6.1 mmol/L
- Lean control:
- BMI \< 25 kg/m2
- waist circumference \< 102 cm
- triglycerides \< 1.0 mmol/L
- HDL-cholesterol \> 1.3 mmol/L
Exclusion
- subjects with plasma LDL-cholesterol \> 5 mmo/L
- diabetes mellitus (defined by oral glucose tolerance test)
- genetic hyperlipidaemia (e.g. FH)
- consumption of \> 30 g alcohol/day
- apolipoprotein E2/E2 genotype
- macroproteinuria
- creatinaemia ( \> 120 umol/L)
- hypothyroidism
- hepatic dysfunction (AST or ALT \> 2x ULN)
- major systemic illness and use of steroids or other agents that may influence lipid metabolism
- cardiovascular event within the past 6 months
- subjects on hypocaloric diets
- anaemia; any significant illness that in the opinion of reviewing physician would bear on the study (e.g. heart murmur or psychiatric conditions)
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00716300
Start Date
July 1 2008
End Date
December 1 2009
Last Update
February 18 2009
Active Locations (1)
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1
University of Western Australia
Perth, Western Australia, Australia, 6000