Status:
COMPLETED
Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis?
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
The pilot study aims to evaluate the effects of a treatment series of gentle joint and muscle movements (in addition to normal optimal care)on lung function, exercise capacity and posture in stable ad...
Detailed Description
Study type: Prospective, single-blinded, randomised control trial Consent * Prospective subjects will be given written and verbal information about the project and will be given at least 24 hours t...
Eligibility Criteria
Inclusion
- Reported postural changes, stiffness, discomfort and/or pain of musculoskeletal origin in the thoracic spine or chest wall.
- Diagnosis of cystic fibrosis (confirmed by genotype or a sweat sodium concentration of \>70mmol/l or sweat chloride of \>60mmol/l)
- Sixteen years of age or over
- Patients in a stable clinical state with lung function at the time of entry that is within 10% of the mean of the last two recordings (separated by at least one month).
- Forced Expiratory Volume in 1 second (FEV1) ≥30% predicted at time of entry to the study.
Exclusion
- Evidence of a current respiratory exacerbation (worsening) as defined by Thornton et al. 2004
- Cor pulmonale (right heart failure)
- Low bone density (Z score \< -3)(WHO Study Group 1994)
- Previous history of spontaneous fractures
- Past history of spinal fracture or other known arthropathic (joint) or spinal disease process
- Currently undergoing musculoskeletal (physiotherapy, chiropractic or osteopathic) treatment
- Pregnancy
- Inability to give consent
- Current enrollment in another research trial.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00716664
Start Date
March 1 2007
End Date
August 1 2008
Last Update
March 11 2009
Active Locations (1)
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1
Royal Brompton Hospital
London, London, United Kingdom, SW3 6NP