Status:
COMPLETED
Comparison of Aprepitant Versus Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting
Lead Sponsor:
Drexel University
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Nausea
Vomiting
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to compare the incidence of nausea, vomiting, need for rescue medication, prolonged PACU time, and unplanned hospital admission in patients with high risk for post-operati...
Detailed Description
Aprepitant, a selective antagonist of neurokinin-1 (NK-1) receptors, blocks the emetic effects of substance P. NK-1 receptors are found on vagal afferents in the gastrointestinal tract and in the nucl...
Eligibility Criteria
Inclusion
- Between 18 and 65 years of age
- American Society of Anesthesiology (ASA) physical status 1-3
- If on oral contraceptive, must be willing to use back up method for 1 month
- Must have 2 risk factors for PONV
Exclusion
- History of vomiting due to middle ear infection, nervous system disorder, or other condition
- Procedure less than 1 hour
- Pregnant or breast feeding
- Antiemetic medication in previous 24 hours
- Narrow-angle glaucoma
- Allergic to belladonna alkaloids
- Hypersensitive to barbiturates
- Prostate hypertrophy
- Severe hepatic disease
- On chemotherapy taking aprepitant
- Fever
- Sepsis
- Taking any of the following medications: Orap, Seldane, Hismanal, Propulsid, Phenytoin, Phenothiazines, Tricyclic antidepressants, Meperidine, Tolbutamide, Aluminum and Magnesium containing Antacids, Anti-cholinergics, Coumadin
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT00717054
Start Date
February 1 2008
End Date
March 1 2010
Last Update
May 20 2014
Active Locations (1)
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1
Hahnemann University Hospital
Philadelphia, Pennsylvania, United States, 19102