Status:
COMPLETED
Effective Treatment for Prescription Opioid Abuse
Lead Sponsor:
University of Vermont Medical Center
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Prescription Opioid Dependence
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
There has been an alarming increase in abuse of prescription opioids in recent years. This project aims to develop an effective outpatient treatment for prescription opioid (PO) abuse that combines an...
Detailed Description
There has been an alarming increase in abuse of prescription opioids in recent years. This project aims to develop an effective outpatient treatment for prescription opioid (PO) abuse that combines an...
Eligibility Criteria
Inclusion
- For inclusion in the proposed studies, subjects must be \> 18 years old and in good health. Subjects must meet DSM-IV criteria for opioid dependence and FDA qualification criteria for buprenorphine treatment, including a history of opioid dependence and significant current opioid use (i.e., opioid-positive urines). Subjects must also be seeking or willing to accept opioid detoxification.
Exclusion
- Because the primary focus of the proposed research is to develop an efficacious intervention for prescription opioid abuse that employs a buprenorphine taper and subsequent naltrexone maintenance, individuals who require ongoing opioid therapy for pain or other chronic medical conditions will be excluded from participating.
- Individuals with evidence of an active psychiatric disorder that may interfere with consent or participation in the research (e.g., psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g., cardiovascular disease) or who are pregnant or nursing will be excluded from participation.
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT00719095
Start Date
April 1 2006
End Date
March 1 2010
Last Update
April 15 2013
Active Locations (1)
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1
Substance Abuse Treatment Center, University of Vermont
Burlington, Vermont, United States, 05401