Status:
COMPLETED
Pre-operative Contrast Enhanced CT to Improve Delineation of the Tumorbed in Radiotherapy for Breast Cancer.
Lead Sponsor:
Maastricht Radiation Oncology
Collaborating Sponsors:
Atrium Medical Center
Maasland Hospital
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Rationale: Whole breast irradiation with 50 Gy after lumpectomy has been shown to reduce the local recurrence rate with a factor 3 to 4. An additional boost of 16 Gy to the tumorbed has been shown to ...
Eligibility Criteria
Inclusion
- Eligible for breast conserving therapy i.e. histologically proven breast cancer
- Operable disease
- Visible mass on mammography or ultrasound \> 0.5 c
Exclusion
- All contra-indications for breast conserving therapy, i.e. previous radiotherapy of the breast, multicentricity, inoperable disease, or too large tumor in a relatively too small breast, pregnancy.
- Contra-indications for intravenous contrast, i.e. iodine allergy, renal malfunction (kreatinine clearance \< 60 ml/min), , previous allergic reaction to i.v. contrast, M. Kahler, use of NSAIDs, Diuretics or Metformine.
- Absence of tumor mass \> 0.5 cm on conventional mammography or ultrasound
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00721058
Start Date
August 1 2008
Last Update
January 5 2010
Active Locations (1)
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1
Maastro clinic
Maastricht, Limburg, Netherlands, 6229 ET