Status:
COMPLETED
Analyzing Genetic Factors Involved in Blood Pressure Changes Due to Salt and Potassium Intake (The GenSalt Study)
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Blood Pressure
Eligibility:
All Genders
18-60 years
Phase:
PHASE3
Brief Summary
High blood pressure is a serious health problem. In terms of diet recommendations, people with this condition are encouraged to eat a low sodium and high potassium diet. It is believed that genetics m...
Detailed Description
High blood pressure is one of the most common health problems among adults. If left untreated, it can lead to heart failure, kidney failure, or stroke. Common causes include stress, diet, diabetes, ki...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Inclusion Criteria for Primary Participants:
- Between 18 and 60 years old
- Systolic blood pressure level of 130 to 160 mm Hg and/or diastolic blood pressure level of 85 to 100 mm Hg
- Both parents (2-generation nuclear family) or at least one parent (at least a 3-generation family) is available and willing to participate in the study
- At least one sibling meets eligibility criteria for participation
- Inclusion Criteria for Sibling/Spouse/Child Participants:
- Siblings and spouses must be between 18 and 60 years old; children must be more than 16 years old
- Lives in the same village as the main study participant
- Exclusion Criteria for All Participants:
- Current stage 2 hypertension (systolic blood pressure level greater than or equal to 160 mm Hg and/or diastolic blood pressure level greater than or equal to 100 mm Hg)
- Current or recent (i.e., less than 1 month before the screening visit) use of antihypertensive medications or medications that affect blood pressure
- Secondary hypertension
- History of clinical cardiovascular disease, including heart attack, congestive heart failure, stroke, and peripheral arterial disease
- Chronic kidney failure or urinary albumin concentration of greater than or equal to 20 mg/dL
- Current diabetes (i.e., fasting serum glucose level greater than or equal to 126 mg/dL) or use of insulin or oral hypoglycemic agents
- Peptic ulcer disease requiring treatment in the 2 years before study entry
- Liver disease requiring treatment in the 2 years before study entry
- Pregnant
- Heavy alcohol drinker (i.e., more than 14 drinks per week)
- Currently adhering to a low sodium diet
Exclusion
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
1906 Patients enrolled
Trial Details
Trial ID
NCT00721721
Start Date
October 1 2003
End Date
May 1 2009
Last Update
July 29 2016
Active Locations (1)
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1
Chinese Academy of Medical Sciences
Beijing, China