Status:
COMPLETED
Renal Protective Effects of Renin Angiotensin System (RAS) Inhibitor in Peritoneal Dialysis Patients
Lead Sponsor:
Sun Yat-sen University
Conditions:
Renal Function Disorder
Eligibility:
All Genders
20-75 years
Phase:
NA
Brief Summary
This is a multicentre study examining the effectiveness of angiotension converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB) or a combination of both in reducing the rate of decline ...
Detailed Description
RRF has been shown to decline progressively with time on dialysis in both CAPD and hemodialysis. Although RRF is an important determinant of mortality and morbidity in peritoneal dialysis (PD) patient...
Eligibility Criteria
Inclusion
- All patients received CAPD more than 1 months
- Subjects of either sex, 20-75 years old
- Residual GFR of 3mL/min per 1.73 m2 or more
- With hypertension
- No history of taking an ACE inhibitor or angiotensin-receptor blockers for at least 1 month
- Provision of written informed consent by subject or guardian
Exclusion
- Underlying medical conditions, such as congestive heart failure, or therapy with an ACE inhibitor or ARB
- Peritonitis or volume overload within the preceding 1 month
- Myocardial infarction within the preceding 6 months
- Clinically significant valvular disease
- Malignant hypertension
- History of hypertensive encephalopathy or cerebrovascular accident within the preceding 6 months
- Any condition that may have precluded a patient from remaining in the study, such as alcohol or drug abuse, chronic liver disease, malignant disease, or psychiatric disorder
- History of allergy or intolerance to an ACE inhibitor or ARB
- Participation in another clinic trial within 2 weeks prior to screening
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00721773
Start Date
September 1 2008
End Date
October 1 2014
Last Update
May 20 2015
Active Locations (1)
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1
The 1st Affiliated Hospital, Sun Yet-sen University
Guangzhou, Guangdong, China, 510080