Status:
COMPLETED
Caspofungin or Micafungin as Empiric Antifungal Therapy for Persistent Fever and Neutropenia
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
Astellas Pharma US, Inc.
Conditions:
Febrile Neutropenia
Eligibility:
All Genders
18+ years
Brief Summary
Invasive fungal infections are an important cause of morbidity and mortality in patients with neutropenia who are receiving chemotherapy for cancer. Early diagnosis of these infections is difficult an...
Detailed Description
Objectives This retrospective cohort analysis of converting from caspofungin to micafungin as empiric antifungal therapy for cancer patients who are persistently febrile and neutropenic after receivi...
Eligibility Criteria
Inclusion
- All patients admitted to BWH/DFCI who received at least 2 doses of caspofungin with an Absolute Neutrophil Count (ANC) \< 500, for persistent febrile neutropenia from 11/1/2005 - 10/31/2006, as there first antifungal agent.
- All patients admitted to BWH/DFCI who received at least 2 doses of micafungin with an Absolute Neutrophil Count (ANC) \< 500 for persistent febrile neutropenia from 11/1/2006 - 10/31/2007 as there first antifungal agent
Exclusion
- Patients receiving an echinocandin antifungal agent (micafungin or caspofungin) for an indication other then empiric therapy in febrile neutropenia
- Patients receiving therapy for an active or on-going invasive fungal infection
- Patients who received both caspofungin and micafungin during the same admission
- Patients with an ANC \> 500 at when either micafungin or caspofungin was started
- Patients who received another antifungal agent for persistent febrile neutropenia, e.g., voriconazole, amphotericin B liposome, posaconazole, etc... Before they received an echinocandin (caspofungin or micafungin) will be excluded
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
323 Patients enrolled
Trial Details
Trial ID
NCT00723073
Start Date
January 1 2008
End Date
May 1 2008
Last Update
August 31 2010
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115