Status:
COMPLETED
Comparison of CT Angiography With Conventional Angiography and Intravascular Ultrasound in Heart Transplant Patients
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
American Roentgen Ray Society
Conditions:
Heart Transplantation
Coronary Artery Disease
Eligibility:
All Genders
18-99 years
Brief Summary
The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for transplant coronary artery disease in the setting of hear...
Detailed Description
Our hypothesis is that state of the art CT coronary angiography can be used to acquire data regarding the coronary arteries in the setting of heart transplant and be used to risk stratify patients wit...
Eligibility Criteria
Inclusion
- Patient referred for coronary angiography and IVUS as part of their standard clinical care;
- Patients must be 18 years of age or older.
- Any ethnic background is acceptable.
Exclusion
- Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
- Patients with heart rate higher than 65 bpm and contraindications for the use of beta-blockers, listed below:
- Systolic blood pressure \< 90mmHg Decompensated congestive heart failure; COPD or asthma in use of bronchodilator; Second or third degree heart block; Severe aortic stenosis, defined by a pressure gradient higher than 50 mmHg and/or the presence of symptoms.
- Patients with contraindications for the use of nitroglycerin, listed below:
- Severe anemia; Increased intracranial pressure; Known hypersensitivity; Use of Sildenafil Citrate (Viagra®)
- Children and pregnant women will be excluded because of risks associated with radiation exposure.
- Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
- Patients unable to give informed consent will be excluded as well.
- Patients with a coronary stent placed.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2013
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00723281
Start Date
January 1 2007
End Date
April 1 2013
Last Update
June 17 2019
Active Locations (1)
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1
UCSF Medical Center
San Francisco, California, United States, 94143