Status:
WITHDRAWN
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction at Altitude
Lead Sponsor:
Loma Linda University
Conditions:
Hypoxic Pulmonary Vasoconstriction
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxyg...
Detailed Description
Three major pathways in addition to oxygen modulate pulmonary vascular tone: 1) nitric oxide, 2) endothelin, and 3) prostacyclin. Considerable animal data support the role of the prostacyclin pathway ...
Eligibility Criteria
Inclusion
- Age: 18 - 80 years
- Healthy physically active males or females
- Have readily measurable tricuspid regurgitation (TR) peak systolic velocity by continuous wave Doppler ultrasound
Exclusion
- Known liver disease
- Pregnancy
- Medications that in the opinion of the investigators could place subjects at increased risk of complications Any other medical condition that in the opinion of the investigators would place the subject at high risk
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00724321
Start Date
July 1 2008
End Date
November 1 2008
Last Update
September 18 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Loma Linda University
Loma Linda, California, United States, 92354