Status:
COMPLETED
Treatment of Acetaminophen Toxicity With N-acetylcysteine
Lead Sponsor:
Akron Children's Hospital
Conditions:
Acetaminophen Toxicity
Eligibility:
All Genders
Brief Summary
Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.
Eligibility Criteria
Inclusion
- Admitted to CHMCA between June 1, 2004 to May 31, 2008 with a qualifying ICD-9 diagnosis code for the following APAP overdose situations; poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0)
- Serum APAP concentrations ≥ 150 g/mL at 4 hours or a serum concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion
- Between the ages of 0-21 years
Exclusion
- Serum APAP concentrations are not actually documented
- Patient did not receive oral or IV NAC treatment
- Patient has a preexisting liver disease such as cirrhosis or hepatitis C
- Patient \> 21 years of age
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2008
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT00725179
Start Date
August 1 2008
End Date
October 1 2008
Last Update
September 9 2011
Active Locations (1)
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1
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44703