Status:
COMPLETED
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Washington University School of Medicine
Conditions:
Emphysema
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
18+ years
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a lung disease that is primarily caused by cigarette smoking. The breakdown of elastin, a protein found in the lungs, can cause lung damage and may cont...
Detailed Description
COPD is a disease in which the lung airways are damaged and partly obstructed, making it difficult to breathe. There is no cure for this disease, and it is the fourth leading cause of death in the Uni...
Eligibility Criteria
Inclusion
- Age equal to or greater than 18 years
- Ability to read and write in English
- Able to participate in the informed consent process
- Acceptable pulmonary function tests (PFTs) done at Barnes-Jewish Hospital within 1 month of study enrollment
- Relatively stable clinical status (not experiencing COPD exacerbation in the previous 6 weeks)
- Global Initiative for Chronic Obstructive Lung Disease (GOLD) class III or IV COPD (FEV1/FVC less than 70% and FEV1 less than 50% of predicted value)
Exclusion
- Pregnant
- Prisoner
- Vulnerable populations
- Pi Z phenotype (i.e., alpha-1 antitrypsin deficiency)
- Significant lung disease, other than COPD / emphysema / chronic bronchitis (e.g., interstitial lung disease, asthma or other predominant airway disease, cystic fibrosis, active tuberculosis)
- Known active hepatitis B, hepatitis C, or HIV/AIDS (found in medical record review; not prospectively evaluated)
- Coexisting active chronic inflammatory or collagen vascular disease, immunodeficiency of any kind, non-cutaneous malignancy (melanoma is an exclusion), or previous organ transplant
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
255 Patients enrolled
Trial Details
Trial ID
NCT00725309
Start Date
November 1 2007
End Date
December 1 2017
Last Update
June 18 2018
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110