Status:
COMPLETED
Subcutaneous Botulinum Toxin for Cutaneous Allodynia
Lead Sponsor:
Stanford University
Conditions:
Pain
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions. The investigators have observed prolonged profound ...
Detailed Description
Post-surgical neuromatous pain patients have marked cutaneous allodynia. Touching their skin with normally non-painful stimuli results in pain. Injected local anesthetics are often effective in provid...
Eligibility Criteria
Inclusion
- Moderate to severe pain (greater than 4/10) of duration more than 6 months despite previous therapy.
- The patient exhibits at least 80% pain relief following injection of local anesthetic subcutaneously into scar as assessed by change in NRS
- The patient reports the presence of hyperalgesia, allodynia, dysesthesia, or hypoesthesia surrounding the scar
- Age 18-100
- Ability to read, write, and converse in English, provide informed consent, and follow study procedures
Exclusion
- Any neuromuscular disorder such as myasthenia gravis, eaton lambert, muscular dystrophy
- Any ongoing legal action related to their pain
- Allergy to local anesthetics
- A current or history of any severe psychiatric disorder
- History of any adverse reaction to botulinum toxin
- History of botulism
- Untreated infection
- Coagulopathy
- Females - positive pregnancy test
- Surgery within the past 6 months at the site of the painful scar
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00725322
Start Date
December 1 2007
End Date
March 1 2013
Last Update
October 25 2017
Active Locations (1)
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1
Stanford University School of Medicine
Stanford, California, United States, 94305