Status:
COMPLETED
Blood Endothelium Biomarkers to Predict Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Atherosclerosis
Percutaneous Coronary Intervention
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
In stent restenosis and myocardial infarction are have been linked the balance between injury and healing of the endothelium These processes can be measured respectively using the number of circulatin...
Detailed Description
Following percutaneous coronary intervention with bare metal stents, the rate of major adverse cardiovascular events including death, myocardial infarction and target lesion revascularization is high ...
Eligibility Criteria
Inclusion
- Age\>18 years old
- Scheduled for PCI
- Clinical evidence of ischemic heart disease and/or abnormal functional study
- New coronary artery lesion \>50%
- treatment with bare metal stent planned
- Informed consent explained, red, understood and signed by the patient
Exclusion
- Pregnancy, birth or lactation period \<6 months ago
- Women of childbearing age who do not intend to use accepted anticonceptive measures or who wish to get pregnant
- Left ventricular ejection fraction \<30%
- Acute coronary syndrome (ST-elevation or not) in the past month
- Planned drug eluting stent implantation
- Lesion in arterial or venous bypass or anastomosis with coronary
- Severe renal insufficiency (creatinine clearance \<30 mL/')
- Severe hepatic insufficiency
- Systemic inflammatory pathology of any kind
- Hematologic or other malignancy, prior radio- or chemotherapy
- Use of corticosteroïds or immune suppression therapy
- Contrast allergy
- Life expectancy \<1 year
- Participation in other clinical study which has not ended yet
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT00725868
Start Date
September 1 2007
End Date
December 1 2010
Last Update
August 26 2011
Active Locations (1)
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1
Service de Cardiologie- Hopital Nord
Marseille, France, 13015