Status:
UNKNOWN
Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers
Lead Sponsor:
Karolinska University Hospital
Collaborating Sponsors:
Ministry of Health and Social Affairs, Sweden
County of Stockholm
Conditions:
Opioid-Related Disorders
Heroin Dependence
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for...
Detailed Description
This initial proof-of-concept study focuses on evaluating whether an NK1 antagonist, aprepitant, can block opiate reward in non-dependent opiate experienced volunteers in response to a standard opiate...
Eligibility Criteria
Inclusion
- Age 18 - 50
- Current opiate use, without dependence
Exclusion
- Clinical diagnosis of opiate dependence
- Positive urine screen for opiates on day of challenge sessions
- Meet diagnostic criteria for any other substance abuse disorder except nicotine within the last 12 months.
- Any ongoing prescription medication other than oral contraceptives or hormone replacement
- Any serious medical condition which in the judgment of the investigators makes administration of opiates medically inappropriate.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00726960
Start Date
January 1 2008
End Date
June 1 2010
Last Update
August 1 2008
Active Locations (1)
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1
Karolinska University Hospital, Huddinge
Stockholm, Sweden, 14186