Status:
COMPLETED
Lung Mucus Hypersecretion and NQO1
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Environmental Exposure
Ozone
Eligibility:
All Genders
18-35 years
Brief Summary
The research plan proposes translational studies in relevant animal models and human subjects in order to identify host (genetic) susceptibility factors that confer vulnerability to the prototypal air...
Detailed Description
Recent epidemiologic studies have re-ignited an old controversy and opinions are forming as to whether mucus hypersecretion is crucial in the etiology of airway disease. For patients with asthma, chro...
Eligibility Criteria
Inclusion
- \-
Exclusion
- subjects with current or past smoking history, acute respiratory illness within six weeks of the study, and significant non-pulmonary disease as determined by the investigator, pregnancy, age \<18 or \>35 yr, or inability to understand the protocol. Subjects will be requested to refrain from anti-histamines, nonsteroidal anti-inflammatory agents, and supplemental vitamins, e.g. C and E, for 1 week prior to, and during lab visits for exposures and follow-up measures.
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Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00729352
Start Date
August 1 2008
End Date
June 1 2012
Last Update
September 29 2014
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710