Status:
COMPLETED
Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
Lead Sponsor:
VA Office of Research and Development
Conditions:
Sleep Apnea
Age
Eligibility:
All Genders
18-89 years
Phase:
NA
Brief Summary
The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly. This proposal focused on key...
Detailed Description
Sleep apnea-hypopnea syndrome (SAS) is a relatively common disorder in the US population with significant adverse health consequences. Despite the high prevalence of SAS in elderly individuals, the un...
Eligibility Criteria
Inclusion
- Healthy older and young adults
Exclusion
- Pregnancy,
- history of active coronary artery disease-including stable and unstable angina,
- recent myocardial infarction,
- history of congestive heart failure,
- stroke,
- excessive daytime sleepiness with Epworth Sleepiness Scale of \>15
- patient with OSA- (Obstructive sleep apnea) on therapy
- depression,
- schizophrenia,
- untreated hypothyroidism,
- diabetes on insulin,
- seizure disorder,
- intrinsic renal and liver disorders,
- failure to give informed consent,
- patients with evidence of pulmonary diseases based on history and abnormal pulmonary function testing, including obstructive (ratio of predicted forced expiratory volume to forced vital capacity, \<80% predicted) or restrictive lung disorders (total lung capacity \<80% predicted) with resting oxygen saturation of \<96% and kyphoscoliosis (chest wall deformities)
- patients on certain medications including, opiates derivatives, stimulants, antidepressants, tranquilizers, anti-psychotic agents, theophylline and other central nervous system altering medications
- history of alcohol or recreational drug use will also serve as grounds for exclusion,
- patients with body mass index (BMI) \>34kg/m2
- subjects with sleep apnea are already using continuous positive airway pressure for more than 7 days as therapy
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT00732199
Start Date
October 1 2008
End Date
April 1 2015
Last Update
June 28 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201