Status:
COMPLETED
Caffeine and Cocaine
Lead Sponsor:
Virginia Commonwealth University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
The University of Texas Health Science Center, Houston
Conditions:
Cocaine Dependence
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
PHASE2
Brief Summary
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse. Another ...
Detailed Description
Specific Aims: Aim 1. To characterize the behavioral and subjective effects of acute caffeine administration in cocaine-dependent subjects, using laboratory measures of impulse control, drug discrimi...
Eligibility Criteria
Inclusion
- Subjects who currently meet DSM-IV criteria for cocaine dependence and healthy controls
- At least one cocaine positive urine during screening.
- Current regular consumption of caffeine.
- Female subjects: a negative pregnancy test.
Exclusion
- Current or past DSM-IV Axis I disorder other than substance abuse/ dependence
- Any significant non-psychiatric medical illness requiring ongoing medical treatment or which would preclude treatment with d-amphetamine or caffeine
- Substance dependence other than cocaine within the last 3 months.
- Positive breath alcohol.
- Positive urine drug screen for drugs other than cocaine or THC at the time of behavioral testing
- For female subjects: known pregnancy or a positive pregnancy test or current breast feeding.
- Diagnosis of Adult Attention Deficit Disorder as determined by: a) meeting DSM-IV criteria for childhood ADHD, b) currently has impairing ADHD symptoms, c) ADHD symptoms can not have remitted at any period since childhood.
- HIV positive.
- I.Q. below 70.
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00733993
Start Date
April 1 2008
End Date
October 1 2011
Last Update
March 22 2017
Active Locations (1)
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1
The University of Texas Health Science Center, Houston
Houston, Texas, United States, 77030