Status:
COMPLETED
Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Scoliosis
Eligibility:
All Genders
11-18 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by...
Detailed Description
At our institution, a study has recently demonstrated that intraoperative infusion of remifentanil is associated with development of clinically relevant acute opioid tolerance in adolescents undergoin...
Eligibility Criteria
Inclusion
- Unpremedicated
- ASA physical status 1 or 2
- Aged 11 - 18
- Scheduled to undergo posterior instrumentation for correction of idiopathic scoliosis
Exclusion
- Chronic opioid use within three months prior to surgery
- Inability to self-administer morphine using a patient-controlled analgesia (PCA) device
- Elective postoperative ventilation
- Obesity (\> 130% ideal body weight)
- Known sensitivity to morphine, remifentanil or any other agent within the standardized protocol
- Failure to obtain written consent or assent
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00737997
Start Date
December 1 2006
End Date
February 1 2008
Last Update
November 19 2014
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8