Status:
COMPLETED
Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Respiratory Insufficiency
Eligibility:
All Genders
18-90 years
Phase:
PHASE3
Brief Summary
Fiberoptic bronchoscopy (FOB) is an important tool for the diagnosis of pulmonary diseases, more particularly in infectious pneumonia. In patients with severe acute hypoxemic respiratory failure, FOB ...
Detailed Description
In acute hypoxemic respiratory failure, FOB with BAL can be life threatening because of a deep oxygen desaturation. Performing FOB under NIV has been shown efficient to prevent episodes of desaturatio...
Eligibility Criteria
Inclusion
- Acute respiratory failure defined by clinical signs of respiratory failure (polypnea, use of accessory respiratory muscle) and a PaO2/FiO2 ratio \< 250
- Need for a diagnosis FOB with BAL
- Informed consent signed
Exclusion
- Contraindication of NIV
- FOB with bronchial biopsies
- Acute coronary syndrome
- Thrombopenia \< 30.000 / mm3 despite platelets transfusion
- Coagulation disorders
- PaO2/FiO2 ratio \< 80 under NIV
- Persistent respiratory acidosis under NIV (pH \< 7,32)
- Propofol allergy
- Xylocaïne allergy
- Pregnancy
- Age \< 18 years or \> 90 years
- Weight \> 150 kg or \< 30 kg
- Inclusion in another clinical protocol
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2011
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00741949
Start Date
September 1 2008
End Date
June 1 2011
Last Update
August 26 2011
Active Locations (2)
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1
University Hospital Bordeaux, Groupe Hospitalier Pellegrin
Bordeaux, France, 33076
2
Centre hospitalier Libourne
Libourne, France, 33505