Status:
COMPLETED
Microvascular Dilatation After Endogenous Induced Hyperinsulinemia
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Hypertension
Obesity
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test). With that the physiological importance of the...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- healthy normotensive subjects:
- 18-60 years
- Caucasian
- Blood pressure \<140/90 mmHg
- obese normotensive subjects:
- 18-60 years
- Caucasian
- Blood pressure \<140/90 mmHg
- BMI 30-38kg/m2
- hypertensive subjects:
- 18-60 years
- Caucasian
- Untreated hypertension \>140/90mmHg.
- Exclusion Criteria for healthy normotensive and hypertensive subjects:
- Obesity (BMI\>27kg/m2)
- Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- Diabetes mellitus according to the criteria of the ADA
- Smoking
- Alcohol use \>4U/day
- Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- Pregnancy
- Wearing contact lenses
- for normotensive obese subjects:
- Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
- Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
- Smoking
- Alcohol use \>4U/day
- Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
- Pregnancy
- Wearing contact lenses
Exclusion
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2010
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00742456
Start Date
January 1 2009
End Date
August 1 2010
Last Update
February 23 2011
Active Locations (1)
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1
University Hospital Maastricht
Maastricht, Netherlands, 6202 AZ