Status:
TERMINATED
The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery
Lead Sponsor:
The Cleveland Clinic
Conditions:
Partial Nephrectomy
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This trial will study the effects of fenoldopam on renal function in patients who have a single kidney undergoing surgery to remove part of that kidney secondary to renal cell carcinoma. The investiga...
Detailed Description
Prospective, randomized, blinded study-dividing patients into one of two groups: fenoldopam or placebo. The infusion will commence after placing the patient in a lateral/flex position during the opera...
Eligibility Criteria
Inclusion
- Patients who have a solitary kidney and present for a partial nephrectomy
- Patients who have one atrophic minimally functioning kidney and present for partial nephrectomy on the other kidney
Exclusion
- History of current renal disease beyond the diagnosis of renal malignancy
- Insulin dependent diabetes mellitus, myocardial infarction without subsequent coronary artery bypass or angioplasty
- History of congestive heart failure, renovascular occlusion greater than 45 minutes or less than 15 minutes, greater than one half of the solitary kidney resected
- A major perioperative complication that would potentially affect postoperative renal function (myocardial infarction, congestive heart failure, pulmonary embolus, massive hemorrhage and hypotension, ureteral obstruction or vascular thrombosis), and evidence of nephrotoxicity due to antibiotics
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00743106
Start Date
September 1 2002
End Date
February 1 2010
Last Update
September 19 2018
Active Locations (1)
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1
Cleveland Clnic
Cleveland, Ohio, United States, 44195