Status:

COMPLETED

Warm Ischemia or Cold Ischemia During Surgery in Treating Patients With Stage I Kidney Cancer

Lead Sponsor:

Wake Forest University Health Sciences

Collaborating Sponsors:

National Cancer Institute (NCI)

Conditions:

Kidney Cancer

Long-term Effects Secondary to Cancer Therapy in Adults

Eligibility:

All Genders

18-120 years

Phase:

NA

Brief Summary

RATIONALE: Warm ischemia is the clamping of blood vessels without cooling the kidney. Cold ischemia is the clamping of blood vessels with kidney cooling. It is not yet known whether warm ischemia is m...

Detailed Description

OBJECTIVES: Primary * Determine the effect of warm ischemia during partial nephrectomy on long-term renal function in patients with solitary stage I renal cortical tumor and normal contralateral kid...

Eligibility Criteria

Inclusion

  • DISEASE CHARACTERISTICS:
  • Diagnosis of solitary renal cortical tumor
  • Tumor size ≤ 4 cm
  • Candidate for open partial nephrectomy
  • Expected ischemia time \< 45 minutes
  • Normal renal function, defined as glomerular filtration rate (GFR) \> 60 mL/min
  • No evidence of distant metastasis
  • No evidence of local invasion of adjacent structures, including the adrenal gland
  • No evidence of tumor extension into the renal venous system
  • No evidence of ureteral obstruction on MAG-3 renal scan
  • No family history of renal cancer
  • PATIENT CHARACTERISTICS:
  • ECOG performance status 0
  • Life expectancy \> 5 years
  • No prior malignancy, except for non-melanomatous skin cancer
  • PRIOR CONCURRENT THERAPY:
  • Not specified

Exclusion

    Key Trial Info

    Start Date :

    August 1 2008

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    June 1 2009

    Estimated Enrollment :

    1 Patients enrolled

    Trial Details

    Trial ID

    NCT00743236

    Start Date

    August 1 2008

    End Date

    June 1 2009

    Last Update

    April 6 2017

    Active Locations (8)

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    Page 1 of 2 (8 locations)

    1

    Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

    Orange, California, United States, 92868

    2

    George Washington University Medical Center

    Washington D.C., District of Columbia, United States, 20037

    3

    University of Chicago Cancer Research Center

    Chicago, Illinois, United States, 60637-1470

    4

    NYU Cancer Institute at New York University Medical Center

    New York, New York, United States, 10016