Status:
COMPLETED
Effect of Quetiapine on Marijuana Withdrawal and Relapse
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
Research Foundation for Mental Hygiene, Inc.
National Institute on Drug Abuse (NIDA)
Conditions:
Marijuana Smoking
Eligibility:
All Genders
21-45 years
Phase:
PHASE2
Brief Summary
The objective of this study is to investigate the interaction between marijuana and quetiapine, with the goal of using this information to improve marijuana treatment outcome.
Detailed Description
The purpose of this study is to determine if quetiapine decreases marijuana relapse in a controlled lab setting. For the purposes of this model, relapse is defined as a return to marijuana use after a...
Eligibility Criteria
Inclusion
- Current marijuana use:average of 2 marijuana cigarettes per day at least 4 times per week for the past 4 weeks
- Able to perform study procedures
- 21-45 years of age
- Women practicing an effective form of birth control (condoms, diaphragm, birth control, pill, IUD)
- Normal body weight
Exclusion
- Current, repeated illicit drug use (other than marijuana)
- Presence of significant medical illness (e.g., diabetes, cardiovascular disease, hypertension, clinically significant abnormalities)
- History of heart disease or current conduction system disease as indicated by QRS duration \> 0.11
- Request for drug treatment
- Current parole or probation
- Pregnancy or current lactation
- Recent history of significant violent behavior
- Major current Axis I psychopathology (major depressive disorder, bipolar disorder, suicide risk, schizophrenia)
- Current use of any prescription or over-the-counter medication
- Prior allergic or otherwise serious adverse reaction to quetiapine
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00743366
Start Date
August 1 2008
End Date
March 1 2009
Last Update
August 18 2017
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032