Status:
COMPLETED
Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) Agonist in Diabetic End-Stage Renal Disease Patients
Lead Sponsor:
The University of Hong Kong
Conditions:
Endstage Renal Disease
Diabetes
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
To test the hypothesis that PPAR-gamma agonist, rosiglitazone, induces carotid plaque regression in diabetic ESRD patients on maintenance PD via its anti-inflammatory property.
Detailed Description
End-stage renal disease (ESRD) patients are at an increased risk of accelerated atherosclerosis and cardiovascular morbidity and mortality. Non-traditional risk factors such as inflammation and insuli...
Eligibility Criteria
Inclusion
- Diabetic ESRD patients receiving long-term PD treatment, with carotid plaque (defined as focal intima-media thickening \>1mm) present on screening ultrasonography
- Patients who provide informed consent for the study
Exclusion
- Patients with systemic inflammatory disease such as systemic lupus erythematosus
- Patients with chronic liver disease or cirrhosis
- Patients with current active malignancy
- Patients with chronic rheumatic heart disease or congenital heart disease
- Patients with poor general condition
- Patients with plan for living related kidney transplant within coming 1 year
- Patients with pre-existing class III/IV heart failure,
- Patients with recurrent hypoglycemia
- Patients already on glitazone treatment
- Female patients with pregnancy
- Patients with contraindications for MRI examination including those with pacemaker or metallic implant.
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00745914
Start Date
September 1 2008
End Date
December 1 2013
Last Update
January 10 2017
Active Locations (2)
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1
Queen Mary Hospital and Tung Wah Hospital
Hong Kong, Hong Kong, Hong Kong, 0000
2
Queen Mary Hospital, Tung Wah Hospital
Hong Kong, Hong Kong, 0000