Status:
COMPLETED
Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC
Lead Sponsor:
Shire
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine if taking Vyvanse with Prilosec OTC or Adderall XR with Prilosec OTC changes how quickly the drug is absorbed into the body and/or changes how much of the dru...
Eligibility Criteria
Inclusion
- Healthy volunteers, age 18 to 45 inclusive at the time of consent.
- Male, or non-pregnant, non-lactating female
- Female subjects must have a negative serum beta Human Chorionic Gonadotropin (HCG) pregnancy test at Screening, and a negative urine pregnancy test on Day -1 after checking into the clinic the day before the first dose of investigational product.
- Body Mass Index (BMI) between 20.0 and 30.0 kg/m² inclusive. This inclusion criterion will only be assessed at the first screening visit.
- Satisfactory medical assessment with no significant or relevant abnormality in medical history, physical examination (PE), vital signs and laboratory evaluation
- Normal or clinically insignificant Screening ECG findings as assessed by the Investigator.
- Ability to swallow investigational products.
Exclusion
- Current or recurrent disease that could affect the action, absorption or disposition of the investigational products, or could affect clinical or laboratory assessments.
- Current or relevant previous history of physical or psychiatric illness, any medical disorder that may require treatment or make the subject unlikely to fully comply with the requirements of the study or complete the study, or any condition that presents undue risk from the investigational products or study procedures.
- Significant illness, as judged by the Investigator, within 2 weeks of the first dose of investigational product.
- History of significant anxiety, tension or agitation as assessed by the Investigator.
- History of or current diagnosis of glaucoma.
- History of a seizure disorder (other than infantile febrile seizures), any tic disorder or a current diagnosis and/or known family history of Tourette's Disorder.
- History of symptomatic cardiovascular disease, advanced arteriosclerosis, structural cardiac abnormality, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, transient ischemic attack or stroke or other serious cardiac problems that may place them at increased vulnerability to the sympathomimetic effects of a stimulant drug.
- History of controlled or uncontrolled hypertension or a resting sitting systolic blood pressure \>139mmHg or diastolic blood pressure \>89mmHg.
- Known family history of sudden cardiac death or ventricular arrhythmia.
- Currently considered a suicide risk, has previously made a suicide attempt or has a prior history of, or is currently demonstrating suicidal ideation.
- Current use of any medication (including prescription, over the counter \[OTC\], herbal or homeopathic preparations) with the exception of hormonal replacement therapy or hormonal contraceptives (Current use is defined as use within 14 days of first dose of investigational product).
- Use of any medication known to inhibit or induce the CYP450 enzymes responsible for the metabolism of the investigational products within 14 days of first dose of investigational product.
- Known or suspected intolerance or hypersensitivity to the investigational product(s), closely related compounds or any of the stated ingredients.
- History of alcohol or other substance abuse within the last year.
Key Trial Info
Start Date :
September 8 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 26 2008
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00746733
Start Date
September 8 2008
End Date
October 26 2008
Last Update
June 14 2021
Active Locations (1)
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1
Clinical Pharmacology of Miami, Inc.
Miami, Florida, United States, 33014