Status:
RECRUITING
NETs: Protection or Harm in Neonatal Inflammation or Infection
Lead Sponsor:
University of Utah
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Necrotizing Enterocolitis (NEC)
Eligibility:
All Genders
Up to 1 years
Brief Summary
This is a prospective in vitro cell biology study of polymorphonuclear leukocyte (PMN) protein synthesis in response to PAF. PMNs from cord blood of premature human infants at risk for NEC (birth weig...
Detailed Description
Many pediatric diseases including Systemic Inflammatory Response Syndrome (SIRS), sepsis, Acute Respiratory Distress Syndrome (ARDS) and neonatal Chronic Lung Disease (CLD) have been associated with d...
Eligibility Criteria
Inclusion
- Patients hospitalized in the NICU who were less than or equal to 1500 grams or less than 30 weeks gestational age at birth; Term infants delivered at UUMC without complication, either via cesarean section or vaginal delivery; Cord blood isolated within first hour of life; and parents or guardians must have signed informed consent.
Exclusion
- Infants with major congenital anomalies will be excluded.
Key Trial Info
Start Date :
October 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
388 Patients enrolled
Trial Details
Trial ID
NCT00747851
Start Date
October 1 2003
End Date
April 30 2026
Last Update
December 5 2025
Active Locations (1)
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1
University of Utah
Salt Lake City, Utah, United States, 84112