Status:
COMPLETED
Killer Immunoglobulin-Like Receptor Transcripts Expression for the Diagnosis of Epidermotropic Cutaneous T Cell Lymphoma
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Mycosis Fungicides
Sezary Syndrome
Eligibility:
All Genders
18-95 years
Phase:
NA
Brief Summary
The most frequent cutaneous T-cell lymphomas (CTCL) are mycosis fungoid and Sezary syndrome. The diagnosis of these lymphomas is difficult using current methods, especially because numerous benign der...
Detailed Description
Background : The most frequent cutaneous T-cell lymphomas (CTCL) are mycosis fungoid and Sezary syndrome. Both are due to the proliferation of a CD4+ T-cell clone in the skin, associated with a blood ...
Eligibility Criteria
Inclusion
- Signed consent
- Subacute/chronic dermatitis (\>7 days) with clinical suspicion for cutaneous T-cell lymphoma
- No past history of lymphoma or other hematologic malignancy
- Skin biopsy for routine histology at inclusion
- Cutaneous T-cell clonality analysis at inclusion
- Sezary cell count on routine blood smear examination in case of erythroderma
- Blood T-cell clonality analysis at inclusion in case of erythroderma
- Age\<18 years
- Skin biopsy for routine histology at inclusion (Possibility, in the 6 previous months of inclusion without any specific treatment other taht local corticoids- amendment n°4)
- Cutaneous T-cell clonality analysis at inclusion (Possibility, in the 6 previous months of inclusion without any specific treatment other taht local corticoids- amendment n°4)
- Realization of a preliminary medical examination
- Sezary cell count on routine blood smear examination in case of erythroderma (Possibility, in the 6 previous months of inclusion without any specific treatment other taht local corticoids- amendment n°4)
- Blood T-cell clonality analysis at inclusion in case of erythroderma (Possibility, in the 6 previous months of inclusion without any specific treatment other taht local corticoids- amendment n°4)
Exclusion
- Adults under tutelage
- Subject not affiliated at the French National health and pensions organization
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
495 Patients enrolled
Trial Details
Trial ID
NCT00748319
Start Date
March 1 2009
End Date
December 1 2011
Last Update
August 22 2012
Active Locations (1)
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1
Groupe hospitalier Henri Mondor - Albert Chenevier
Créteil, France, 94010