Status:
COMPLETED
Slope of the Pressure-Time Waveform Predicts Resistance and Compliance in Mechanically Ventilated Subjects
Lead Sponsor:
Gregory A. Schmidt
Conditions:
Respiration Disorders
Eligibility:
All Genders
18-99 years
Brief Summary
There are two fundamentally different ways to ventilate critically ill patients: constant flow, volume-preset modes (such as volume assist-control) and pressure-preset modes (such as pressure-control ...
Detailed Description
Aim 1: To compare the respiratory system resistance and elastance obtained during constant-flow, volume-preset ventilation (using conventional means) and during pressure-preset ventilation (by analyzi...
Eligibility Criteria
Inclusion
- Subjects may be included in the study if they meet the following inclusion criterion and no exclusion criteria:
- Adult medical or surgical ICU patients who are mechanically ventilated.
Exclusion
- Subjects with planned extubation at time of screening
- Subjects who are judged too hemodynamically unstable by their attending physician to participate in the study
- Subjects on high-frequency ventilation
- Subjects whose oxyhemoglobin saturation cannot be maintained at 88% or greater
- Subjects with large air leaks around the endotracheal or tracheostomy tube
- Subjects younger than 18 years old
- Inability to obtain informed consent from the subject or the subject's authorized representative
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00750074
Start Date
November 1 2007
End Date
October 1 2010
Last Update
February 28 2017
Active Locations (1)
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1
Univesity of Iowa
Iowa City, Iowa, United States, 52242