Status:
COMPLETED
Effect of Fibre Products on Appetite and Weight
Lead Sponsor:
Imperial College London
Conditions:
Obesity
Eligibility:
All Genders
21-65 years
Phase:
NA
Brief Summary
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel. SCFA are thought to have direct ben...
Detailed Description
This is a dose finding study in healthy overweight to obese human volunteers (BMI 25- 35) to find the level of oral supplementation with propionate that increases plasma propionate levels to 10x the c...
Eligibility Criteria
Inclusion
- Healthy male and female volunteers aged between 21 and 65 years
Exclusion
- Weight change of more than 3kg in the preceding 2 months
- Current smokers
- Substance abuse
- Excess alcohol intake
- Pregnancy
- Diabetes
- Cardiovascular disease
- Cancer
- Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
- Kidney disease
- Liver disease
- Pancreatitis
- Use of medications including: anti inflammatory drugs or steroids, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00750438
Start Date
September 1 2008
End Date
October 1 2012
Last Update
November 19 2019
Active Locations (1)
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1
Hammersmith Hospital
London, UK, United Kingdom, W12 0NN