Status:
TERMINATED
Hypertonic Modulation of Inflammation Following Injury
Lead Sponsor:
University of Washington
Conditions:
Hemorrhagic Shock
Traumatic Brain Injury
Eligibility:
All Genders
15+ years
Brief Summary
This project seeks to determine the effect of prehospital resuscitation with hypertonic saline vs. conventional crystalloids on the inflammatory response after injury. The leading cause of late mortal...
Detailed Description
This was an ancillary study to the larger clinical trials of prehospital hypertonic resuscitation conducted by the resuscitation outcomes consortium. This study investigated markers of immune function...
Eligibility Criteria
Inclusion
- Blunt or Penetrating trauma with prehospital systolic blood pressure \< 70 or 70-90 mmHg with Heart rate \> 108 OR Blunt trauma with prehospital Glasgow coma score \<= 8
Exclusion
- Age \< 15 yrs
- Known prisoners
- Pregnancy
- Ongoing Cardiopulmonary resuscitation (CPR)
- Burns \< 20%
- Hypothermia \< 28 C
- \> 2 liters intravenous fluid prior to study fluid administration
- \> 4 hour from time of dispatch
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT00750997
Start Date
November 1 2007
End Date
December 1 2009
Last Update
May 1 2017
Active Locations (2)
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1
University of Washington
Seattle, Washington, United States, 98104
2
University of Toronto
Toronto, Canada