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Status:

UNKNOWN

Screening Methods in Finding Lung Cancer Early in Current or Former Smokers

Lead Sponsor:

British Columbia Cancer Agency

Conditions:

Lung Cancer

Tobacco Use Disorder

Eligibility:

All Genders

50-75 years

Phase:

NA

Brief Summary

RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This clinical trial is studying screening methods to see how well they find lung cancer early i...

Detailed Description

OBJECTIVES: * To develop a new multi-modal screening strategy and integrated methods to detect lung cancer early in current and former smokers. * To evaluate the impact of the screening modalities on...

Eligibility Criteria

Inclusion

  • DISEASE CHARACTERISTICS:
  • Current or former smoker
  • A former smoker is defined as one who has stopped smoking ≥ 1 year but \< 15 years ago
  • Estimated 1-year lung cancer risk ≥ 1%
  • PATIENT CHARACTERISTICS:
  • ECOG performance status 0-1
  • Not pregnant
  • Willing to undergo a spiral chest CT scan
  • No severe heart disease (e.g., unstable angina or chronic congestive heart failure)
  • No acute or chronic respiratory failure
  • No bleeding disorder
  • No other medical condition that, in the opinion of the investigator, would preclude the participant's safety during study participation or that would unlikely benefit the participant from screening due to shortened life expectancy from the co-morbidity
  • No diagnosis of cancer, except for any of the following that were previously treated ≥ 5 years ago:
  • Non-melanomatous skin cancer
  • Localized prostate cancer
  • Carcinoma in situ of the cervix
  • Superficial bladder cancer
  • No known reaction to xylocaine, salbutamol, midazolam, or alfentanil
  • PRIOR CONCURRENT THERAPY:
  • More than 2 years since prior chest CT scan
  • No concurrent anti-coagulant treatment (e.g., warfarin or heparin)

Exclusion

    Key Trial Info

    Start Date :

    September 1 2008

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    Estimated Enrollment :

    2504 Patients enrolled

    Trial Details

    Trial ID

    NCT00751660

    Start Date

    September 1 2008

    Last Update

    March 9 2012

    Active Locations (6)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 2 (6 locations)

    1

    University of Calgary Health Sciences Centre

    Calgary, Alberta, Canada, T2N 4N1

    2

    British Columbia Cancer Agency - Vancouver Cancer Centre

    Vancouver, British Columbia, Canada, V5Z 4E6

    3

    Nova Scotia Cancer Centre

    Halifax, Nova Scotia, Canada, B3H 1V7

    4

    Margaret and Charles Juravinski Cancer Centre

    Hamilton, Ontario, Canada, L8V 5C2