Status:
TERMINATED
AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Osteoarthritis
Eligibility:
All Genders
40+ years
Brief Summary
The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.
Detailed Description
This study will test the hypothesis that knee trauma (as exemplified by the arthroscopy procedure) causes inflammation that alters muscle activation patterns locally and also disrupts the balance betw...
Eligibility Criteria
Inclusion
- Age 40 or older
- Potential candidate for knee arthroscopy for medial
- Meniscal tear confirmed on MRI
- Prior meniscal resection at least 1 year prior with a persistent knee effusion
- Body mass index between 25-35 kg/m2
Exclusion
- Knee injury in the 1 month before the initial study evaluation
- Knee surgery within 1 year before the initial study evaluation
- Pace-maker or defibrillator, 2nd or 3rd degree heart block, or other abnormal rhythms
- Current diagnosis of diabetes mellitus, a fasting glucose\>100mg/dl or \>140 mg/dl 2 hour after a glucose challenge
- Current diagnosis of an inflammatory condition (e.g. rheumatoid arthritis, gout, etc)
- Untreated thyroid disease
- Morbid obesity (body mass index \>35)
- Neuropathy or nerve damage
- Stroke or transient-ischemic attacks (mini-stroke)
- Recent diagnosis of congestive heart failure or heart attack
- Use of prednisone or chemotherapy, steroid or other joint or ant-inflammatory agents in the past 3 months
- Current use of medications that influence heart rate
- Cognitive impairment that limits your ability to provide informed consent
- Pregnancy
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00752271
Start Date
May 1 2008
End Date
May 1 2010
Last Update
December 18 2009
Active Locations (1)
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1
NIA Clinical Research Unit
Baltimore, Maryland, United States, 21225