Status:
UNKNOWN
Deep Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Lead Sponsor:
Tel-Aviv Sourasky Medical Center
Collaborating Sponsors:
Brainsway
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
50-80 years
Phase:
PHASE2
Brief Summary
The primary objective of this trial is to assess the ability of Transcranial Magnetic Stimulation with H2 coil to prefrontal and parieto-temporal cortex to improve cognitive performance in patients wi...
Detailed Description
Primary outcome measure: ADAS-COG (time frame baseline, 2 months, 4 months) Secondary outcome measure: CGI-C, Neuropsychological computerized test (Mindstream), FAB,ADL, Beck Depression Inventory-time...
Eligibility Criteria
Inclusion
- Written informed consent will be obtained
- diagnostic evidence of probable AD consistent with DSM IV
- stable treatment with Acetylcholine-Esterase Inhibitors or/and Memantine for 5 weeks prior to screening
- stable dose treatment with other drugs
- MMSE \<25
Exclusion
- Patients with neurological or psychiatric disorders that affect cognition but are distinguishable from AD
- Patients who are unwilling or unable to fulfill the requirements of the study
- Severe personality disorder
- Malignant or untreated Hypertension
- History of Epilepsy
- History of Head trauma
- Metal implant in head, cardiac pacemaker, medical pump
- Drug or alcohol addiction
- Involvement in any other clinical trial during the preceding 3 month
- Patient who are unwilling or unable to give Informed Consent
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2012
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00753662
Start Date
November 1 2008
End Date
November 1 2012
Last Update
September 13 2011
Active Locations (1)
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1
Tel Aviv Sourasky Medical Center, Neurology Department
Tel Aviv, Israel, 64239