Status:
COMPLETED
Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Tic Disorder
Tourette Syndrome
Eligibility:
All Genders
18-65 years
Brief Summary
This study will investigate the sensation that many people with Tourette syndrome (TS) experience before they have a motor tic. It will also test whether blocking the sensation causes the tic to stop....
Detailed Description
Objectives: We will investigate whether the sensory experience that precedes motor tics in Tourette syndrome is generated in the peripheral nervous system and whether it may result from altered senso...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Tourette subjects must be 18-65 years of age of any race, gender, or handedness. They must be able to sit for at least 2 hours and remain at the testing site for up to 8 hours. They must be able to follow instructions and participate in reporting sensory experiences. The upper extremity tic to be studied must occur at least once a minute, but no more frequently than once every 5 seconds. Individuals with comorbid attention deficit disorder (ADD or ADHD) or with obsessive-compulsive disorder (OCD) will not be excluded.
- Healthy volunteers must be 18-65 years of age, of any race, gender, or handedness.
- EXCLUSION CRITERIA:
- Inability to stop taking all central-acting medications, including those used to treat tics, for at least one week prior to the study
- Current use of coumadin, heparin, or lovenox
- Any additional movement disorder, including tremor, myoclonus, or dystonia
- A diagnosis of major depression or bipolar disorder
- Frequent or severe headaches
- Any history of or current experience of hallucinations
- Any history of a seizure or epilepsy or a family history of epilespy
- Any prior brain injury, brain tumor or other lesion, stroke, or surgery
- A diagnosis of increased intracranial pressure
- A history of significant heart disease
- Any history of hearing problems, or abnormal results on auditory testing (part I or II)
- Any of the following: pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments (part I and II only)
- Any history of work as a welder or metal worker (part I and II)
- Current pregnancy
- Tobacco use (cigarette, chewing, or other) in the month prior to the study (part II)
- Diagnosis of, treatment for, or self-report of alcohol abuse (alcoholism) (part I)
- Cocaine use in the year prior to involvement in the study (part I)
- Use of any medication within one month prior to the study with cholinergic or anticholinergic properties, including (but not limited to): nicotine patch, nicorette gum, atrovent, enablex, toriaz, ditropan, vesicare, detrol, sanctura, artane, Aricept, cogentin, akineton, zanaflex, norflex, flexeril, lomotil, mototen, levsin, razadyne, exelon (part I)
- Peripheral neuropathy or carpal tunnel syndrome (part I)
- Inability to hold head still for 10 minutes (part I).
Exclusion
Key Trial Info
Start Date :
September 15 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 25 2016
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00755339
Start Date
September 15 2008
End Date
October 25 2016
Last Update
October 25 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892