Status:
COMPLETED
Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly
Lead Sponsor:
Peking University
Collaborating Sponsors:
Institute of reproductive and Child Health
National Natural Science Foundation of China
Conditions:
Hyperhomocysteinemia
Eligibility:
All Genders
60-74 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate whether low dose complex B-vitamins (folic acid,vitamin B6 and vitamin B12) can lower the risk of developing hyperhomocysteinemia in an apparently healthy popu...
Detailed Description
Hyperhomocysteinemia has been well known as an independent risk factor for CVD. Numerous studies have demonstrated that certain kinds of vitamin B(folic acid,vitamin B6 and vitamin B12)can reduce Hcy ...
Eligibility Criteria
Inclusion
- Male and female residents living in the field site for at least 12 months
- Aged 60-74 years
Exclusion
- History of chronic disease and taking medications for treatment such as CVD, COPD, cancer, severe renal and liver disease, diabetes.
- Use of multivitamins, and individual vitamins such as folic acid, B12, or B6 in the last 6 months.
- Taking medications known to interfere with folate metabolism, including methotrexate, tamoxifen, L-DOPA, niacin, phenytoin, bile acid sequestrants; anticonvulsant medications (such as dilantin, phenytoin, and primidone), Metformin, Sulfasalazine.
- Conditions that prevent participation or compliance such as Downs syndrome, mental problems, or severe cognitive impairment
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
390 Patients enrolled
Trial Details
Trial ID
NCT00755664
Start Date
July 1 2007
End Date
September 1 2012
Last Update
June 8 2015
Active Locations (1)
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1
The maternal and Children health care hospital
Yuanshi County of Shijiazhuang, Hebei, China, 050000