Status:
COMPLETED
Study of Dietary Phosphate and Mineral Homeostasis in Early Chronic Kidney Disease
Lead Sponsor:
University of British Columbia
Conditions:
Kidney Diseases
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
This study is designed to describe the physiological response to increased and decreased dietary phosphate intake on various parameters of mineral metabolism in the blood and urine of individuals with...
Detailed Description
The potential benefits of implementation of phosphate management earlier in CKD (Stages 3/4) are threefold: 1) prevention of vascular damage early in the progression of CKD thus reducing risk of cardi...
Eligibility Criteria
Inclusion
- CKD patients with CKD stage 3 and 4 (eGFR \< 60 ml/min and \> 15 ml/min per 1.73 m2, not requiring dialysis).
- Normal serum phosphate stable over three months (\> 0.87 mmol/L and \< 1.70 mmol/L)
- Not yet following a low phosphate diet as reported by the patient or the renal dietitian (\<1500mg/d)
- Over 19 years of age
Exclusion
- Body mass index \<20 kg/m2
- Current use of phosphate binders or active vitamin D or phenytonin (which induces vitamin D catabolism)
- Primary parathyroid defects
- Diagnosed osteoporosis
- Gut absorption defects
- Liver disease
- Pregnancy or lactation
- Patients hospitalised within the last 4 weeks
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00755690
Start Date
September 1 2008
End Date
March 1 2010
Last Update
February 19 2014
Active Locations (1)
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1
St. Paul's Hospital
Vancouver, British Columbia, Canada