Status:
COMPLETED
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway
Lead Sponsor:
Shanghai Changzheng Hospital
Conditions:
Colorectal Disease
Eligibility:
All Genders
25-75 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to delineate the effects of preoperative oral carbohydrate on immediate postoperative insulin resistance (PIR) in patients undergoing elective open colorectal cancer resec...
Detailed Description
Postoperative insulin resistance (PIR) is a central feature of postoperative metabolism response to surgical injury, resulting in decreased insulin-stimulated glucose uptake in skeletal muscle and adi...
Eligibility Criteria
Inclusion
- The present study employed 32 patients, who underwent elective open colorectal resection for colorectal carcinoma
Exclusion
- Diabetes mellitus or impaired glucose tolerance
- Medication affecting insulin sensitivity
- Weight loss greater than 10 per cent during the previous 6 months
- Signs of distant metastasis by CT scanning
- Renal insufficiency (creatinine, \> 3 mg/dl; hemodialysis)
- Hepatic insufficiency (Child-Pugh class, ≥ B)
- Gastro-oesophageal reflux disease
- Gastrointestinal obstruction
- Conditions (including pharmacological treatment) known to affect gastric emptying rate
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2007
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00755729
Start Date
November 1 2006
End Date
March 1 2007
Last Update
September 19 2008
Active Locations (1)
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1
Department of General Surgery, Shanghai Chang Zheng Hospital,
Shanghai, Shanghai Municipality, China, 200003