Status:
COMPLETED
Food Exposure Therapy in Anorexia Nervosa
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
The Hilda & Preston Davis Foundation
National Alliance for Research on Schizophrenia and Depression
Conditions:
Anorexia Nervosa
Eligibility:
All Genders
18-45 years
Brief Summary
This is a research study to determine whether a medication called D-cycloserine (DCS) in combination with a type of psychotherapy called Exposure Therapy is helpful to patients with anorexia nervosa.
Detailed Description
This is a research study to determine whether a medication called D-cycloserine (DCS) in combination with a type of psychotherapy called Exposure Therapy is helpful to patients with anorexia nervosa. ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Patients:
- DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype) on admission
- Subjects will have achieved 90% of ideal body weight (IBW)
- Age 18-45
- Medically stable
- Participation in inpatient treatment
- Subjects must have signed informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
- Exclusion Criteria for Patients:
- Any other current major Axis I disorder, except OCD or MDD (mild)
- On psychotropic medication, including benzodiazepines (At the start of the study, subjects will be free of fluoxetine for 4 weeks, and free of all other medications for a minimum of 2 weeks.)
- History of a seizure disorder
- Abnormal liver function
- Renal insufficiency
- Known hypersensitivity to D-cycloserine
- Pregnant or lactating
- Acute suicidality (suicidality or self injury in the last 3 months)
- Inclusion Criteria for Healthy Controls:
- BMI ≥ 19.0 kg/m2
- Age 18-45 years
- Subjects must have signed informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
- Exclusion Criteria for Healthy Controls:
- Current Major Axis I disorder (including Eating Disorder, Major Depression,Bipolar Disorder, Schizophrenia, Substance Abuse/Dependence) History of an Eating Disorder
- Current use of psychotropic medication or other medication known to affect mood and/or anxiety (e.g. b-agonist inhalers, oral steroids)
- Major medical condition
Exclusion
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00755820
Start Date
January 1 2008
End Date
January 1 2012
Last Update
October 26 2012
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032