Status:
COMPLETED
"Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study" (Citrugrêle)
Lead Sponsor:
Nantes University Hospital
Conditions:
Healthy Subjects
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
The specific aim of this study is to determine whether oral citrulline administration enhances whole body protein synthesis in healthy humans in the postabsorptive state. Protein metabolism will be as...
Eligibility Criteria
Inclusion
- Healthy adult between 18 and 45 years of age
- Absence of any earlier supplementation with citrulline, glutamine, ornithine a-ketoglutarate, or stimol®
- Absence of any treatment with anabolic agents during the month prior to inclusion in the study- No current artificial feeding (enteral or parenteral)
- No renal, cardiac, respiratory or hepatic insufficiency
- No chronic inflammatory disease (intestinal or other
- No current corticotherapy
- Fasting blood glucose below 6mmol/L (126 mg/dL)
- Body mass index between 19 and 24.9
- Patient able to understand benefits and risks of protocol
- Not pregnant, taking oral contraceptive measure if able to procreate
- Subject affiliated to French health insurance (Sécurité Sociale)
- Informed consent form signed
- No concomitant participation to another clinical trial, and compliance with the exclusion period required by law
Exclusion
- Subject not fulfilling inclusion criteria
- Subject mentioned in articles L1121-5 to L1121-8 of "code de la santé publique"
- Subject for whom the participation in this clinical trial would result, by cumulating stipends received for other clinical trials, in earning more than 4500 € within 12 consecutive months
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00756080
Start Date
September 1 2008
End Date
January 1 2009
Last Update
March 9 2010
Active Locations (1)
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1
CHU Nantes
Nantes, France, 44093