Status:
COMPLETED
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
Lead Sponsor:
University of Florida
Conditions:
Hyperuricemia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury. We hypothesize that...
Detailed Description
The study will be a prospective, double-blind, placebo-controlled, randomized, clinical trial, initiated and implemented conjointly by the Nephrology and Cardiovascular Surgery Departments at Shands H...
Eligibility Criteria
Inclusion
- Age 18 years or older, and
- Undergoing elective cardiothoracic surgery(s), alone or in combination with other procedures/surgery(s): thoracic aortic aneurysm, cardiac valves, coronary artery bypass grafting, abdominal thoracic aneurysm, other CV surgery, and
- Preoperative serum uric acid \> 6.5 mg/dL, and
- Preoperative estimated glomerular filtration rate of \>30ml/min/1.73m2 or higher, but less than 60ml/min/1.73m2
Exclusion
- Prior history of allergy/adverse reaction to Rasburicase
- History of any organ transplant
- Preoperative intra-aortic balloon pump (IABP)
- Known glucose 6-phosphate dehydrogenase (G6PD) deficiency
- Current use of natriuretic peptides
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00756964
Start Date
October 1 2008
End Date
August 1 2011
Last Update
September 3 2012
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32610