Status:
COMPLETED
Copeptin in the Diagnosis and Differential Diagnosis of Diabetes Insipidus. The CoSIP-Study
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Diabetes Insipidus
Eligibility:
All Genders
18+ years
Brief Summary
Evaluation of Copeptin in the differential diagnosis of diabetes insipidus.
Detailed Description
Background: Plasma arginine vasopressin (AVP) measurement is recommended for the differential diagnosis of diabetes insipidus and polydipsia. However, AVP measurement is cumbersome. AVP is derived fr...
Eligibility Criteria
Inclusion
- All patients \> 18 years who are tested for the diagnosis of DI because of a history of polyuria (\> 40 ml/kg per 24 hours) in the presence of polydipsia Patients with known DI will be contacted whether they agree to participate in the study and to undergo again a water deprivation test to measure copeptin to confirm the diagnosis.
Exclusion
- Polyuria of other origin, i.e. prostate hyperplasia, diabetes mellitus.
- Pregnancy
- The investigators do not perform the water deprivation test in patients with: \*renal insufficiency
- uncontrolled diabetes mellitus
- hypovolemia of any cause
- uncorrected deficiency of adrenal or thyroid hormones
- No informed consent
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00757276
Start Date
June 1 2008
End Date
October 1 2014
Last Update
December 15 2014
Active Locations (1)
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1
University Hospital Basel
Basel, Basel, Switzerland, 4031